3. Date of birth: 09/10/1974 4. Place of birth: Hoai Duc, Ha Noi
5. Admission decision number: Number 5713/QĐ-ĐHKHTN, dated on December 19th, 2014 signed by Rector of VNU University of Science.
6. Changes in academic process: No
7. Official thesis title: “Study on characteristics allele frequencies of STR loci (AmpFlSTR® Identifiler® Plus Kit) of some ethnic groups in Vietnam used for DNA identification”
8. Major: Biochemistry 9. Code: 624201166
10. Supervisors: Assoc. Prof. Nguyen Quang Huy, Assoc. Prof. Trinh Hong Thai
11. Summary of the new findings of the thesis
- Collected and DNA analyzed by AmpFlSTR® Identifiler® Plus kit of 13,396 blood samples from unrelated individuals of the 9 populous ethnic groups in Vietnam.
- Analyzed, determined allele frequency of 15 locus STR by AmpFlSTR® Identifiler® Plus kit of 9 the main ethnic groups living in Vietnam, eligible in forensic DNA testing, through which identified:
+ 54 low alleles frequency are currently not included in the Allelic ladder standard of all ethnic groups studied.
+ Based on the calculation of genetic distance (D) and constructed a phylogenetic tree showing that: Kinh population in the North, Central and Southern Vietnam are closely related. Muong, Tay and Nung ethnic groups are a group with close relationship with Kinh ethnic group; Hoa, Thai and Khmer ethnic groups have a longer genetic distance. The H'mong and Dao tribes split into two separate and distinct other groups.
+ Identified the highly effective loci in DNA human identification for Vietnamese are: FGA, D2S1338, D18S51, D8S1179, D19S433. The low effective loci are TPOX, CSF1PO, TH01, D3S1358.
12. Practical applicability, if any
Applying the allele frequency of the 9 populous ethnic groups in Vietnam including: Kinh, Tay, Thai, Muong, Khmer, Hoa, Nung, H'mong and Dao to can be applied in forensic DNA testing (DNA human identification, DNA parentage testing).
13. Further research directions, if any
- Some low alleles frequency specific to ethnic groups in the Vietnamese should continue to be studied.
- Need to expand the study to determine the allele frequency of 15 STR loci in other ethnic groups living all over Vietnam (besides 9 ethnic groups studied) such as Gia Rai, E De and Ba Na...
14. Thesis-related publications
[1] Nguyen Quang Vinh, Trinh Tuan Toan, Phan Dieu Linh, Pham Quang Khai, Nguyen Thi Thanh Nga, Nguyen Quang Huy (2014), "Determining rare alleles 9.1 at the D7S820 DNA locus in Vietnamese by the Identifiler Plus kit ", VNU Scientific Journal; Natural Science and Technology (6S-C), pp.618-625.
[2] Trinh Tuan Toan, Pham Ngoc Son, Do Hoai Nam, Le Thanh Cu, Luong Thi Phuc, Nguyen Quang Huy, Trinh Hong Thai (2015), "Frequency of allele STR of 15 locus Identifiler™ of Tay and Khmer ethinic group in the Southern Vietnam ", VNU Journal of Science: Natural Sciences and Technology 31(4S), pp.437-444.
[3] Trinh Tuan Toan, Ha Quoc Khanh, Vu Le Loi, Nguyen Quang Vinh, Nguyen Quang Huy (2017), "Research on diversity of Y-STR haplotype of random populations in Kinh Vietnamese", VNU Journal of Science; Natural Science and Technology 33(2S), pp.212-218.
[4] Trinh Tuan Toan, Ha Quoc Khanh, Nguyen Van Huy, Nguyen Quang Huy (2018), Allele frequency of locus STR Powerplex Fusion kit of Kinh ethinic group (Vietnam), Scientific report on National Conference on Biotechnology 2018 (NCBT-2018), ISBN 978-604-913-759-4, pp.133-137.
